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Molecular mechanisms and pharmacogenetic determinants of II–III generation antihistamines efficacy in allergic bronchial asthma: personalized therapy prospects

Borodulina E.A., Yakovleva E.V., Borodulin B.E., Gladunova E.P., Marchenko S.D., Krylova O.V., Mamontova E.R., Rekalo A.R., Minnullina Z.R., Bagirova B.R., Salpagarova A.A.

Introduction. Allergic bronchial asthma (BA) is accompanied by activation of histamine H1/H4 receptors and variable response to antihistamines. The aim of this review is to analyze the molecular mechanisms of action of second- and third-generation antihistamin…