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DEVELOPMENT AND VALIDATION OF HPLC-MS/MS METHOD OF DETERMINATION OF A NEW VALPROIC ACID DERIVATIVE AND 1,3,4-THIADIAZOLE IN RAT BRAIN

Malygin A.S., Popov N.S., Demidova M.A., Shatokhina N.A.

Introduction. To assess the pharmacokinetic indices of new drugs, it is necessary to develop analytical methods for determining their concentration in biological objects. Purpose of the study. Development and validation of HPLC-mass spectrometric methods for t…