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RANK/RANKL/OPG SYSTEM COMPONENTS AND INTERLEUKINS 6, 8 16 IN BLOOD SERUM OF PATIENTS WITH PRIMARY BONE NEOPLASMS

Kushlinskii N. E., Gershtein E. S., Timofeev Yu. S., Korotkova E. A., Babkina I.V., Zuev A.A., Soloviev Yu.N.

Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…