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THE ROLE OF CHROMOSOMAL V(D)J RECOMBINATION OF LYMPHOCYTES IN THE FORMATION OF ANTITUMOR IMMUNITY AND THE EFFECTIVENESS OF IMMUNOTHERAPY

Sultanbaev A.V., Musin Sh.I., Menshikov K.V., Izmailov A.A., Nasretdinov A.F., Sultanbaevа N.I., Menshikova I.A., Tsimafeyeu I.V., Lipatov D.O., Sultanbaev M.V., Lipatov O.N., Kudlay D.A.

Introduction. The effectiveness of antitumor immunity is determined by various mechanisms of recognition of tumor antigens, while the diversity of the repertoire of antigenic receptors is determined by V(D)J recombinations in maturing T and B cells. The aim of…