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PROGNOSTIC SIGNIFICANCE OF KIT AND PDGFRA MUTATIONS FOR GASTROINTESTINAL STROMAL TUMORS

Tsyganova I.V., Beliakov I.S., Anurova O.A., Mazurenko N.N.

Introduction. Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of GI tract, are characterized by KIT and PDGFRA activating mutations that are predictive factors. KIT and PDGFRA mutations are present in 85% of GISTs and are associated…