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Molecular Medicine
Found: 9
The study is devoted to the identification of changes in the proteomic profile of senescent mesenchymal stromal cells of adipose tissue, which determine the modulation of the macrophage phenotype and are involved in the pathogenetic cascade of the formation of…
Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…
Introduction: Biorevitalization is a modern method of injection cosmetology aimed at correcting age-related skin changes by introducing hyaluronic acid (HA) and additional biologically active components. The hyaluronic gel for microimplantation and mesotherapy…
Introduction. Allergic bronchial asthma (BA) is accompanied by activation of histamine H1/H4 receptors and variable response to antihistamines. The aim of this review is to analyze the molecular mechanisms of action of second- and third-generation antihistamin…
Introduction. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that is highly expressed in healthy lungs and performs homeostatic function there. However, the exact mechanisms of development of these diseases remain unk…
Osteopontin (OPN) is a highly phosphorylated multifunctional glycosphoprotein with important functional activity in cancer and cardiovascular diseases, diabetes mellitus (DM), kidney and liver pathology, inflammatory process, and also influencing cell viabilit…
Introduction. The molecular mechanisms of the development of the prostate tumor pathology are associated with the activation of both androgen-dependent and androgen-independent signaling pathways, accompanied by the development of chronic inflammation and hypo…
The review presents data on the role of the nuclear factor NF-κB and the von Hippel-Lindau protein (VHL) in the development of kidney cancer. Chemo- and radioresistance, specific for renal cell carcinoma, represented a significant problem in the treatment of p…
Introduction. The search for criteria for the prediction of the efficacy of targeted therapies will allow not only to optimize the readings, but also to improve the results of treatment of patients with metastatic kidney cancer. The aim of the study is the inv…