ОБЗОР2026 · pp. 79–86
Molecular mechanisms, pharmacological properties, and applications of PARP inhibitors in ovarian cancer therapy
Relevance. PARP inhibitors (PARPi), have emerged as a significant development in the treatment of high-grade serous ovarian cancer that is associated with mutations in BRCA1/2 and genes of other homologous recombination proteins. These drugs exploit synthetic …