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Molecular Medicine Peer-reviewed scientific journal

Found: 5

ОБЗОР2026 · pp. 100–106

Molecular predictors of efficacy of single-stranded yeast RNA and ascorbic acid complexes: from critical quality attributes to personalized immunomodulation

Introduction. Single-stranded yeast RNA–ascorbic acid complexes are of interest as a class of natural immunomodulatory systems combining activation of innate immune pattern-recognition receptors with redox-modulating and epigenetic effects of vitamin C. Russia…

10.29296/24999490-2026-03-14Details ↗
ОБЗОР2026 · pp. 65–74

YEAST RNA AS A SOURCE OF IMMUNOMODULATORY NUCLEOTIDES: FROM BIOCHEMISTRY TO CLINICAL APPLICATION

Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…

10.29296/24999490-2026-02-09Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2026 · pp. 31–38

Molecular patterns of RNA pathogens and immune response to exogenous RNA: recognition mechanisms and therapeutic potential

Introduction. Innate immunity represents the first line of defense against pathogens, based on recognition of conserved molecular patterns (PAMPs) through specialized pattern recognition receptors (PRRs). RNA-containing viral patterns are of particular importa…

10.29296/24999490-2026-01-04Details ↗
ОБЗОР2025 · pp. 76–83

Synergism of ascorbic acid and RNA interferon inducers in antiviral immunity activation: molecular mechanisms and therapeutic perspectives

Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…

10.29296/24999490-2025-06-10Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

EXPRESSION OF INNATE IMMUNE RECEPTORS AND TRANSCRIPTIONAL REGULATION OF T-HELPER CELLS IN EXPERIMENTAL ILEITIS AND CONDUCT OF THE SIMVASTATIN AND ARIL-1

Introduction. The pathogenesis of inflammatory bowel disease is complex and multifactorial. Studies have led to the current concept that the T-helper cells are components of the adaptive immune response whereas Toll-like receptors, NOD-like-receptors, RIG-I-li…

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