ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Kotlovskiy M.Yu., Pokrovskiy A.A., Osedko A.V., Osedko O.Ya., Kotlovskaya O.S., Yakimenko A.V., Kurdoyak E.V., Yakimovich I.Yu., Aksyutina N.V., Titova N.M., Kotlovskiy Yu.V., Dygai A.M.
Introduction. Carrier protein OATP1B1, encoded by the SLCO1B1gene, is involved in the transport of simvastatin into liver cells. SLCO1B1 gene polymorphisms influence on the functionality of the transporter, which could reflect on the efficacy and safety of tre…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Chertovskikh Ya.V., Shuev G.N., Popova N.V., Rudykh Z.A., Maksimova N. R., Grachev A.V., Sychev D. A.
Introduction. SLCO1B1 encodes the organic anion-transporting polypeptide which has been shown to regulate the hepatic uptake of statins. SLCO1B1*5 genetic variant is associated with the high risk for statin-induced myopathy in patients with statins therapy. Ai…
Research article2014
Shuev G.N., Sychev D.A., Khokhlov A.A., Grachev A.V., Beloshitskaya T.A.
Introduction.SLCO1B1 encodes the organic anion–transporting polypeptide which has been shown to regulate the hepatic uptake of statins. SLCO1B1*5 genetic variant is associated with statin-induced myopathy. The aim of the study. Aim of the study is to research …