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ABERRANT METHYLATION OF PROMOTER REGIONS OF SOX7, P15INK4B AND WNT PATHWAY ANTAGONIST GENES IN PATIENTS WITH MYELODYSPLASTIC SYNDROME

Kostroma I.I., Gritsaev S.V., Sidorova Zh.Yu., Tiranova S.A., Svitina S.P., Drizhun Yu.S., Martinkevitch I.S., Abdulkadyrov K.M., Kapustin S.I., Chechetkin A.V.

Introduction. Hypermethylation of CpG islands in tumor-suppressor genes are supposed to be a key mechanism of the development of the myelodysplastic syndrome (MDS) The aim of the study. To determine the association between methylation status of SOX7, p15INK4b,…