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GENE SLCO1B1 ASSOCIATED WITH STATIN-INDUCED MYOPATHY IN RUSSIAN AND SAKHA (YAKUTIA) STATIN INTAKE PATIENTS SUFFERED FROM HYPERLIPIDEMIA

Chertovskikh Ya.V., Shuev G.N., Popova N.V., Rudykh Z.A., Maksimova N. R., Grachev A.V., Sychev D. A.

Introduction. SLCO1B1 encodes the organic anion-transporting polypeptide which has been shown to regulate the hepatic uptake of statins. SLCO1B1*5 genetic variant is associated with the high risk for statin-induced myopathy in patients with statins therapy. Ai…