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Molecular Medicine
Found: 37
Introduction. Cancer drug resistance is driven among others, by non-genetic mechanisms. These processes may involve transcription factors dysregulation, modifications in gene expression, as well as epigenetic mechanisms such as DNA methylation, histone modific…
Tick bite is traditionally viewed in clinical practice primarily as an event associated with the risk of pathogen transmission. Although this interpretation is epidemiologically justified, it does not capture the molecular layer that develops within the first …
The development of metastases even long after treatment is one of the most important problems of medicine. There are mechanisms helping cancer cells to survive at various steps of metastasis. The ability of cancer cells to turn into dormant state characterizin…
Introduction. Oxidative stress (OS) occurs in various pathological processes, and acting as a nonspecific link in their pathogenesis. Less is known about its physiological role. The aim of study. Analysis of the results of world literature data and our own res…
Introduction. Overcoming resistance to anticancer drugs in the treatment of malignant neoplasms is an urgent problem of recent decades. Unfortunately, there is no single mechanism for the development of resistance. Alterations that occur in a normal cell durin…
Personalized therapy allows to reveal subtypes of diseases with similar symptoms but various molecular mechanisms of development. Different -omics (genomics, epigenomics, transcriptomics, proteomics ets) are used to divide the diseases into subtypes. Transcrip…
Introduction. Early diagnostics of such oncological disease as cutaneous malignant melanoma is strictly important for the decrease of mortality. It is known that microRNA expression in melanoma cells and in bening melanocytic nevi is different, that can be use…
Introduction. Under the influence of glioma cells, peritumoral zone astrocytes may acquire tumorigenic phenotype, particularly due to the suppression of immunocompetent cells. The aim of the study. Investigate the changes in the gene expression profile of glio…
The neurotrophic hypothesis of depressive disorders has gained widespread recognition nowadays. This review is devoted to the brain-derived neurotrophic factor (BDNF) system in the pathogenesis of depression and major depressive disorder. We describe the struc…
At present biomedical research is based on joint fulfillment of theoretical and experimental investigations of various derivatives of potential therapeutic destination. Well-balanced combination of noted studies is provided for the high reliability of ensemble…
The review summarizes a number of published reports about the influence of total hormonal and metabolic disturbances on the functioning system mother – placenta – fetus in the organism of the women with obesity and gestational diabetes mellitus. The circadian …
The review article discusses the principles of a personalized approach to changing the functional activity of the immune system based on micronutrients. The activity of the immune cells has been demonstrated to depend on the level of supplied not only macro- b…
Introduction. The incidence of infectious and inflammatory diseases, including sepsis, increases with the age, which is explained by the age-related decrease in the content of sex steroids. However, the features of the course of systemic inflammatory responses…
Introduction. Glycine is well-known to have a positive effect in the treatment of patients suffered from an ischemic stroke. Vasodilatation is one of the main parts of the action of this amino acid at the molecular level. Simultaneously, the increase of oxygen…
Introduction. Papillary thyroid cancer (PTC) is the most common malignancy of the endocrine system. As the most frequent genetic alteration BRAF V600E mutation in PTC leads to changes in the activity of intracellular signaling pathways. As a result, expression…
Introduction. The physiological state of the skin vasculature is largely determined by the influence of environmental factors, including the alteration of the oxygen partial pressure. Obviously, the epidermis, as the surface layer of the skin, should play a ke…
The data concerning the changes of expression and posttranslational modification of the human protein under the influence of the external and internal irradiation in vivo and in vitro are presented in this review. The investigation of protein expression and po…
Introduction. Recent reports have demonstrated patients with malignant neoplasias have different molecular genetic aberrations. But there are few data available concerning patients with multiple primary tumors (MPT). Aim. To study molecular genetic alterations…
Introduction. Hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Molecular mechanisms of fibrogenesis are associated with the activation or inhibition of signaling pathways, which are controlling…
Introduction. EGFR mutation and EML4-ALK fusion are the most clinically significant genetic alterations in non-small cell lung cancer. Numerous studies have been devoted to EGFR mutations and their association with phenotypic clinical and pathological characte…