ОБЗОР2026 · pp. 67–72
Pathogenetic mechanisms of myocardial damage in coronary heart disease
coronary artery disease, epithelial-mesenchymal transition, cadherins, connexins, transforming growth factor-β, pannexins
Found: 9
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 54–59
MOLECULAR MECHANISMS OF NEUROPROTECTION OF 3-[(E)-3-(3,5-DITRET-BUTYL-4-HYDROXYPHENYL)-3-OXOPROP-1-ENYL]-6-METHOXY-CHROMENE-4-ONE IN EXPERIMENTAL TRAUMATIC BRAIN INJURY
Introduction. Neuroprotection in traumatic brain injury is a promising area of therapy for cerebral disorders. Neuroprotective effect can be implemented by a action on variety molecular targets, a change in the activity of which leads to the elimination of pat…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 50–55
INDUCTION OF APOPTOSIS OF PROSTATE CANCER CELLS BY THE EXTRACT OF THE FRESHWATER SPONGE
Introduction. Prostate cancer (PC) is by far the most commonly diagnosed malignant neoplasm of the urinary system. The pathogenesis and molecular mechanisms of prostate cancer remain incompletely understood. There are reports of the presence in the extracts of…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2021
A comparison of the protein composition from coronary atherosclerotic plaque at different stages of development
Background: The aim of this study was to investigate individual changes of protein expression in atherosclerotic plaques of coronary arteries at different stages of development of coronary atherosclerosis. Methods: The research object was homogenates of athero…
ОБЗОР2021
ON THE ROLE OF PCSK9 IN THE DEVELOPMENT OF ATHEROSCLEROSIS: MOLECULAR ASPECTS
Due to the discovery of the proprotein convertase subtilisin/kexin type 9 (PCSK9) and the establishment of its role in lipoprotein metabolism, it became possible to deliver new groups of effective drugs for the treatment of dyslipidemia. The main function of P…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
PROTEOMIC AND METABOLOMIC MANIFESTATIONS OF DIFFERENT VARIANTS OF APOLIPOPROTEIN E GENES POLYMORPHISM IN OBESE PATIENTS
Introduction. Currently questions on the role of genes polymorphism that regulate metabolism and implicated in metabolic disorders are disputed. Objective. The study of proteomic and metabolomic manifestations of different variants of apolipoprotein E genes po…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
THE ROLE OF OXIDATIVE PROTEIN MODIFICATION IN REDOX-DEPENDENT REGULATION OF TUMOR CELL APOPTOSIS
Introduction. According to modern understanding, oxidative stress along with apoptosis dysregulation plays an important role in the pathogenetic mechanisms of tumor growth; formation of oxidative stress is accompanied by oxidative modification of cell protein …
Research article2014
GALECTIN-1 INDUCES MITOCHONDRIAL APOPTOTIC PATHWAY IN CD4+ T-CELLS
Introduction. Galectin-1 binds to cell surface glycoprotein and participates in cooperation of immune cells. It is supposed that the CD4+- lymphocytes can be target for immunosuppressive activity of galectin-1. However, there is no sufficient information about…
Research article2013
BLOOD LYMPHOCYTE APOPTOSIS IN NORM AND PATHOLOGY
With the purpose to determine the content of apoptotic lymphocytes of venous blood in norm and pathology there were examined 40 primary donors of blood, 14 patients with closed abdominal trauma complicated by acute blood loss of at least 30% of circulating blo…