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Molecular Medicine Peer-reviewed scientific journal

Found: 6

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 14–20

Levels of GFAP, Iba1, TNF-α, and caspase-3 in the cingulate cerebral cortex of mice after intraperitoneal lipopolysaccharide

Introduction. Bacterial lipopolysaccharide (LPS) affects the structure and function of nervous tissue cells. The aim of the study: to explore the impact of intraperitoneal LPS given to mice on levels of such markers as glial fibrillar acidic protein (GFAP), ad…

10.29296/24999490-2025-06-03Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 43–48

Prognostic significance of CD68+ macrophages in autoimmune inflammation in experimental study

Introduction. Autoimmune oophoritis is one of the causes of premature ovarian insufficiency in 3–40% of cases. Representative diagnosis is possible only through histological examination of ovarian biopsy material, which complicates the identification of early …

10.29296/24999490-2025-04-07Details ↗
ОБЗОР2023 · pp. 11–19

THE ROLE OF CHROMOSOMAL V(D)J RECOMBINATION OF LYMPHOCYTES IN THE FORMATION OF ANTITUMOR IMMUNITY AND THE EFFECTIVENESS OF IMMUNOTHERAPY

Introduction. The effectiveness of antitumor immunity is determined by various mechanisms of recognition of tumor antigens, while the diversity of the repertoire of antigenic receptors is determined by V(D)J recombinations in maturing T and B cells. The aim of…

10.29296/24999490-2023-04-02Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2021

INNATE AND ADAPTIVE IMMUNITY DURING INFECTION AND IMMUNIZATION WITH INACTIVATED TICK-BORNE ENCEPHALITIS VACCINE

Introduction. Viral infections induce cellular and humoral immunity that provide virus elimination. Extracellular presentation of antigens of formaldehyde-inactivated vaccines causes mainly humoral immune response with risk of persistent infection. The aim of …

10.29296/24999490-2021-06-07Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2020

A MODEL OF SURFACE PLASMON RESONANCE IMMUNOSENSOR FOR DETERMINING AUTOANTIBODIES TO GLUTATHIONE-S-TRANSFERASE IN SERUM SAMPLES

Introduction. The quantitative determination and isotyping of autoantibodies to a clinically significant protein – glutathione-S-transferase (GST) in blood serum samples is relevant for monitoring and predicting the dynamics of autoimmune processes. The aim of…

10.29296/24999490-2020-06-06Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

EXPRESSION OF INNATE IMMUNE RECEPTORS AND TRANSCRIPTIONAL REGULATION OF T-HELPER CELLS IN EXPERIMENTAL ILEITIS AND CONDUCT OF THE SIMVASTATIN AND ARIL-1

Introduction. The pathogenesis of inflammatory bowel disease is complex and multifactorial. Studies have led to the current concept that the T-helper cells are components of the adaptive immune response whereas Toll-like receptors, NOD-like-receptors, RIG-I-li…

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