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THE MECHANISM OF TOLERANCE OF THE ESTROGEN-INDEPENDENT BREAST CANCER CELLS TO HYPOXIA:THE ROLE OF SNAIL1 AND BETA-CATENIN, THE EPITHELIAL-MESENCHYMAL TRANSITION PROTEINS

Stefanova L.B., Scherbakov A.M., Sorokin D.V., Shatskaya V.A., Krasilnikov M.A.

The main goal of the project was to study the heightened tolerance of the resistant breast cancer cells to hypoxia. Two in vitro cultured breast cancer cell lines, the estrogen-dependent MCF-7 cells and the resistant ER-negative HBL-100 cells were used in the …