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Molecular Medicine
Found: 12
This review was conducted to systematize data on the association of matrix proteinase gene polymorphisms (MMP, ADAMTS, ADAM) with the risk of developing osteoarthritis. Material and methods. A systematic literature search of PubMed and Web of Science databases…
Sarcopenia is a progressive and generalized pathology of skeletal muscles of multi-factor nature. The present review focuses on the analysis of molecular genetic markers that may contribute both to sarcopenia risk formation and the variability of diagnosticall…
Introduction. Vitamin D is one of the main regulators of phosphorus-calcium metabolism. Vitamin D availability is determined by both external and genetic factors. The genetic contribution to the 25 (OH) D level is estimated to range from 23 to 77%. According t…
Introduction. New technologies of DNA genotyping and sequencing contribute to the rapid accumulation of our knowledge about human genomic variations and search for inherited determinants of complex genetic traits. There is a large amount of data on association…
The efficacy of bronchial asthma therapy is one of the most urgent problems in allergology and pulmonology. The efficacy of leukotrienes modifiers in bronchial asthma therapy is not achieved in 35–78% cases. In addition, there are data on unwanted drug reactio…
Introduction. Endometrial hyperplasia represents a chronic progressive disease characterized by high prevalence among women in older age groups. The aim of the study. To study the involvement of combinations of candidate genes in the formation of hyperplastic …
Preeclampsia is the pregnancy complication characterized by the presence of arterial hypertension and proteinuria. Preeclampsia is the leading cause of maternal and perinatal morbidity and mortality. To date, there are more than 40 advanced theories of etiopat…
Introduction. Uterine fibroids – a benign tumor, growing from immature muscle cells of the vascular wall of the uterus. It ranked first among the benign tumors of the genital organs, with one in ten suffers from gynecological patients with uterine myoma. The a…
Renal cancer is among the most common oncourological diseases, and represents a heterogeneous group of tumors, which up to 80% is a clear cell renal cancer (CCRC). The study of rare hereditary forms of CCRC led to identification of the VHL gene; germinal VHL m…
Introduction. Preeclampsia is one of the most frequent complications of pregnancy. Disease is based on the pathology of the vascular system of a pregnant woman. One of the candidate genes of preeclampsia is a gene encoding a protein receptor type 2A to activin…
In the literature review there are presented the modern views on the concept of the pathogenesis of Crohn’s disease (CD). There has been analyzed the role of defects in innate immunity in CD associated with mutations in genes NOD2/CARD15, ATG16L1, IRGM which r…
The article provides a brief overview of the evolution of views on the phenomenon of pleiotropy. We discuss with assessment of pleiotropic effects significance in the formation of human pathological states, above all – multifactorial diseases (MFD). Pleiotropi…