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Molecular Medicine
Found: 11
Introduction. Short peptides are considered a promising class of geroprotective agents capable of modifying key molecular mechanisms of aging, from epigenetic regulation of gene expression to maintenance of neuroendocrine and antioxidant homeostasis. Laborator…
Introduction. Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer characterized by frequent mutations in the ARID1A gene and low sensitivity to standard-of-care chemotherapeutic agents. The aim of the study. To determine the role of A…
Introduction. The initial state of an organism and its initial reactivity are the main prognostic criteria for the individual radiosensitivity evaluation. Particulars of the DNA structure and chromatin conformation determine in many respects the cell radiosens…
Introduction. The difference in the responsibility of organisms’ influences on the results of biological experiments and medical intervention. The chromatin conformational state is one of the main factors determining the cell response to the effect of differen…
The review highlights current data on molecular pathogenesis and potential markers of clear cell renal cell carcinoma, obtained in MultiOmyx studies. Key molecular mechanisms of the pathogenesis of RCC are the loss of functions of the VHL, PBRM1, SETD2, BAP1, …
Introduction. Changes in the structural organization of the cell nucleus often precede the degeneration of the nerve cell. Histone H4 trimethylated on lysine 20 (H4K20me3) may act as one of the markers of neurodegenerative processes. The aim of this paper was …
Renal cancer is among the most common oncourological diseases, and represents a heterogeneous group of tumors, which up to 80% is a clear cell renal cancer (CCRC). The study of rare hereditary forms of CCRC led to identification of the VHL gene; germinal VHL m…
Hepatocellular carcinoma (HCC) is the most prevalent form of malignant liver cancer characterized by late detection time and highly aggressiveness. The main risk factors for HCC development are chronic infections of hepatitis B and C viruses, cirrhosis, liver …
The formation of properties promoting malignant transformation begins before the appearance of tumor cells at the level of inflammatory and precancerous processes. The basis for these properties is genomic instability of tumor cells. Genetic instability manife…
Introduction. DNA methylation is a key epigenetic modification providing the regulation of human genome activity in ontogenesis. DNA methylation patterns were described in the chromosomes from adult lymphocytes. DNA methylation patterns of the chromosomes from…
Argirophilic proteins of nucleolar organizer regions (Ag-NOR) pose a wide group of nucleolar proteins specifically stained by AgNO3. Expression level of Ag-NOR proteins in proliferating cells, including tumor ones, is commonly high. Nucleophosmin/B23 and nucle…