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SOMATIC MUTATIONS ARE THE MAIN EVENTS OF CARCINOGENESIS IN CLEAR CELL RENAL CANCER

Mikhaylenko D.S., Kolpakov A.V., Kushlinskii N.E.

Renal cancer is among the most common oncourological diseases, and represents a heterogeneous group of tumors, which up to 80% is a clear cell renal cancer (CCRC). The study of rare hereditary forms of CCRC led to identification of the VHL gene; germinal VHL m…