This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 120
The aim of this review is to analyze current understanding of the molecular mechanisms of altered sensitivity of the arterial baroreflex and peripheral chemoreflex and their potential association with perioperative complications. Material and methods. The revi…
Introduction. Cancer patients have a high risk of developing venous thromboembolic complications, which worsen the outcomes of antitumor treatment and are the second leading cause of death after cancer progression. Objectives – to assess the effect of modern a…
Relevance. Modern approaches to detecting circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA) demonstrate high potential for improving the accuracy of molecular diagnostics of tumors and require a comprehensive analysis of all stages, from the biology of f…
Objective. Mixed organometallic complexes containing amino acids and water-soluble vitamins as ligands are promising research subjects in organic and physical chemistry. The practical applications of these compounds may include medicine, where they are conside…
The aim of this review is to systematize current knowledge on the role of selenium in biochemical processes and in the development of diseases associated with its deficiency or excess. Material and methods. A comprehensive search and analysis of publications f…
Аmphocyte production and indirectly reflect the state of the adaptive immune system. Their concentration in dried blood spots can be determined by quantitative polymerase chain reaction (qPCR). Currently, these markers are used for neonatal screening of primar…
Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the stimulating effect on the organs of genitourinary system. Purpose of study. Study of stimulating effect on cellular proliferation of…
Introduction. To date, there are a number of relevant studies devoted to changes in the LPO-AOP system indicators in adolescents and young adults with migraine. However, specific quantitative data and relationships between LPO-AOP indicators and migraine requi…
Introduction. Autoimmune oophoritis is one of the causes of premature ovarian insufficiency in 3–40% of cases. Representative diagnosis is possible only through histological examination of ovarian biopsy material, which complicates the identification of early …
Introduction. Cardiovascular diseases are the main cause of death and disability in the world population. Serotonin plays a significant role in the development and progression of atherosclerotic processes due to its two classical functions – platelet aggregati…
Introduction. The significant increase in obesity among children and adolescents necessitates the search for ways to prevent and treat it. Inflammation in obesity is the main mechanism leading to comorbid changes. Aim of the study. To establish correlations be…
Introduction. Studying the effect of the nitric oxide (II) donor, S-nitrosoglutathione, on the relative amount of selectin P in HUVEC cell lysates in vitro may contribute to fundamental understanding of the effect of the nitric oxide system on the adhesive fun…
Introduction. It is assumed that in degenerative diseases of the retina, photostimulation with fractal dynamics signals activates neuroplasticity, increasing the effectiveness of visual rehabilitation. Previously, we demonstrated the positive effect of fractal…
Introduction. Additionally to electrophysiological and clinical methods the neurofilament light chains (Nf-L) concentration in blood plasma is considered as a marker for predicting functional outcomes. The aim of the study. Assessment of neurofilament light ch…
Introduction. Allergic bronchial asthma (BA) is accompanied by activation of histamine H1/H4 receptors and variable response to antihistamines. The aim of this review is to analyze the molecular mechanisms of action of second- and third-generation antihistamin…
Introduction. Heat shock proteins (HSPs) are a group of highly prospective compounds that can be used in various branches of clinical medicine, such as neurology, pharmacology and oncology. Studying the content of these proteins in various parts of the brain o…
Introduction. This review is devoted to the study of the structure, properties, evolution of hemoglobins, biochemical and clinical aspects of the use of neuroglobin (Ngb) and fetal hemoglobin (HbF) in health and in ischemic hypoxia of the brain. Material and m…
Introduction. Angiogenesis regulators are of particular interest as new serum markers in cancer patients, since they reflect the intensity of tumor growth and metastasis. Currently, many works are dedicated to the study of vascular endothelial growth factor (V…
Background. During the last decades, data on potential cytoprotective effects of decarboxylated and deiodinated endogenous compounds – metabolites of thyroid hormones, constituting the thyronome, have been accumulated. The aim of this review is to systematize …
Introduction. The study of the effect of peroxynitrite, as a product of nitric oxide (II), on the culture of endothelial cells in vitro can contribute to fundamental ideas about the violation of the adhesive function of the endothelium when changing the synthe…