ОБЗОР2026 · pp. 67–72
Pathogenetic mechanisms of myocardial damage in coronary heart disease
coronary artery disease, epithelial-mesenchymal transition, cadherins, connexins, transforming growth factor-β, pannexins
Found: 11
ОБЗОР2026 · pp. 95–103
THE POSSIBILITIES OF TELEMEDICINE TECHNOLOGIES TO PROVIDE A PERSONALIZED APPROACH IN CARDIOLOGY THROUGH THE USE OF WEARABLE DEVICES
Cardiovascular diseases remain one of the main causes of hospitalization, disability, and mortality. The usual monitoring model and rare face-to-face visits often do not keep up with the actual clinical dynamics. This partly explains the growing interest in we…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 57–64
The role of the AKT1 gene in the pathogenesis of type 2 diabetes mellitus and its complications
Introduction. Type 2 diabetes (T2D) is a chronic metabolic disorder. The number of diabetic people is increasing. AKT1 is a protein kinase and a participant in the PI3K/AKT/mTOR signaling pathway. The aim of the study was to analyze the association of polymorp…
ОБЗОР2024 · pp. 13–20
INTERLEUKIN-11 AND CARDIOVASCULAR PATHOLOGY
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. An important task in cardiology is the search and study of new biomarkers. Scientific interest is actively focused on the study of interleukin-11 (IL-11). The purpose of the literature…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2021
SALIVA CONCENTRATION OF SIRTUINS: PERSPECTIVES OF APPLICATION FOR CORONARY HEART DISEASE DIAGNOSTICS AND AGING RATE
The aim is the comparative analysis of saliva concentration of sirtuins, in middle age and elderly people without cardiovascular pathology (CP) and with coronary heart disease (CHD). Methods. Saliva was obtained from healthy donors (73 persons without CP, «nor…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2020
TECHNOLOGY FOR THE DETERMINATION OF MINOR FRACTIONS OF MODIFIED LIPOPROTEINS-α IN CORONARY ATHEROSCLEROSIS
Introduction. For the first time in clinical practice, diagnosis of different stages of lipidemia is conducted according to the level of blood lipids, lipoproteinsand catalase activity. This diagnostic approach can detect early stage of lipidemia against the p…
ОБЗОР2018
SALIVA AS A BIOLOGICAL OBJECT FOR NON-INVASIVE MOLECULAR DIAGNOSIS OF CARDIOVASCULAR DISEASES
Cardiovascular diseases (CVD) are considered to be one of the leading causes of lethality in patients of older age groups. In the last decade, the issue of finding a material for effective non-invasive diagnosis of CVD has become urgent. The review considers t…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018
PHARMACOGENETIC TESTING BY POLYMORPHIC MARKERS G1846A (CYP2D6*4) AND C100T (CYP2D6*10) CYP2D6 GENE IN CORONARY HEART DISEASEPATIENTS, TAKING BETA-BLOCKERS IN THE SAKHA REPUBLIC (YAKUTIA)
Introduction. The aim of this study to determine carrier frequencies of polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease (CHD) patients in Russian and Yakut ethnic groups. The association between theadmin…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
INFLUENCE OF SLCO1B1 GENE C.T521>C POLYMORPHISM ON THERAPY WITH SIMVASTATIN IN CORONARY HEART DISEASE PATIENTS
Introduction. Carrier protein OATP1B1, encoded by the SLCO1B1gene, is involved in the transport of simvastatin into liver cells. SLCO1B1 gene polymorphisms influence on the functionality of the transporter, which could reflect on the efficacy and safety of tre…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
INFLAMMATORY MARKERS OF CORONARY ATHEROSCLEROSIS
Introduction. Currently in the world there are conducted numerous studies on the search for biomarkers associated with increased risk of coronary heart disease (CHD). The aim of the study. The study of the levels of such inflammatory biomarkers as the tumor ne…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
PREDICTION THE RISK OF ISCHEMIC STROKE ON THE BASE ON GENETIC [APOE (Ε2, Ε3, Ε4), ACE (I / D), MTHFR (677S> T)] AND NON-GENETIC FACTORS WITH THE USE OF MODERN METHODS OF THE THEORY OF RECOGNITION BY PRECEDENTS
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…