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INFLUENCE OF CYTOTOXIC CHEMOTHERAPY ON THE ERCC1, XPD AND DPYD EXPRESSION IN COLORECTAL CANCER LIVER METASTASES

Paltseva E.M., Varlamov A.V., Sekacheva M.I., Fedorov D.N., Skipenko O.G.

Introduction. The elevated expression of components of DNA repair system ERCC1 (excision repair cross-complementing group 1) and XPD (Xeroderma pigmentosum group D) is associated with the lack of efficacy of DNA–damaging cytotoxic platinum-based preparations. …