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THE PREVALENCE OF CYP2C19*2, *3 POLYMORPHISMS AMONG RUSSIANS AND YAKUTS WITH PEPTIC ULCER DISEASE, LIVING IN SAKHA REPUBLIC (YAKUTIA)

Temirbulatov I.I., Ivashchenko D.V., Rudykh Z.A., Popova N.V., Tayurskaya K.S., Chertovskikh Ya.V., Sychev D.A.

Introduction. Proton pump inhibitors (PPI) are widely spread as antisecretory drugs for a treatment of acid diseases, such as the gastric ulcer. Most of the proton pump inhibitors are inactivated in the liver by cytochromes P450 2C19 (CYP2C19) to the form of i…