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Molecular Medicine
Found: 22
Introduction. Sirtuins (SIRTs) are NAD+-dependent histone deacetylases involved in the intracellular regulation of multiple biological processes including DNA repair, autophagy, inflammation, oxidative stress defence and metabolism associated with age-associat…
Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins …
The article describes the results of an experimental study of tissue-engineering constructions based on lactic acid – poly-L,L-lactide, containing allogeneic cells of various tissue origin. Aim: to show experimentally the possibility of using an allogeneic tis…
Introduction. Violation of the skin barrier can be considered as an initial stage in the development of atopic dermatitis, leading to further skin inflammation [2]. Transmembrane proteins such as claudin-1, claudin-7, occludin and E-cadherin are known to be th…
The aim of this work is to study the effect of the AED peptide on fibroblast differentiation of human skin when aging in vitro. Methods. The study was conducted on DF-1 cell line (human dermal fibroblasts (mesenchymal stem cells)) isolated from the skin of the…
Introduction. The work is devoted to study of new medication Novacutan SBio and Novacutan YBio as potential geroprotectors for biorevitalization of the skin. Klotho was used as a marker – to assess the overall aging of cells; MTH1 – the antioxidant status of c…
Introduction. Advances in biology and medicine in particular in the field of cell technologies allow us to test eye stem cells as an alternative to surgical treatment of corneal pathology. An option to increase the resistance of stem cells to adverse microenvi…
Introduction. Uveal melanoma is a malignant neoplasm of neuroectodermal origin, prone to early metastasis. The tumor microenvironment, including «inflammatory cells» and connective tissue cells, affects its progression, angiogenesis and metastasis. Purpose. To…
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
Introduction. Inflammatory myofibroblastic neoplasm (IMN) of the spleen is extremely rare. It is often benign lesion, represented mainly by fusiform myofibroblasts and inflammatory cells (plasma, lymphocytes and eosinophilic granulocytes). Clinically, the sple…
Introduction. Skin aging is a natural process that cannot be stopped. However, there are many ways to help stop premature aging of the skin and reduce the signs that have already appeared. One of them is the subcutaneous administration of preparations containi…
Introduction. Application of placenta hydrolysate in cosmetology opens a new page in anti-aging therapy. Numerous studies have confirmed the antioxidant, anti-inflammatory, anti-pigmental properties of placenta hydrolysate preparations, as well as activation o…
Introduction. Prolapse of pelvic organs being extremely common in the female population, hence, it is important to search for factors of prolapse pathogenesis to identify markers of the optimal time for surgical intervention. The aim of the study is to investi…
Introduction. The Alzheimer disease (AD) is the socially important neurodegenerative disease. The promising way of the early lifetime diagnosis of the AD is the investigation of the expression of signal molecules by cells in a cerebrospinal fluid, blood lympho…
Introduction. At the present time the attention to the development of implant coating is growing in the fields of surgery, odontology, traumatology and orthopedy because of its possibility to improve the stability of metal implants on the one hand and to provi…
Introduction. Contracting deep scars are almost unresponsive to conservative treatment and often require repeated surgical intervention. These scars represent a serious problem in skin therapy after the extensive damage. Just the impairment of processes of the…
Introduction. Amniotic tissue sheath is unique in its wound-healing properties, including anti-fibrotic, immunosuppressive and antibacterial features, as well as in its ability to stimulate cell proliferation and migration. These properties are further complem…
Introduction. Diploid human fibroblasts lines (DHFL) are widely used in diagnostic virology and experimental studies. One of the directions of use DHFL in virology and immunology is to create on their basis of a test system for determining the activity of inte…
Introduction. Biomimetic peptides – are synthetic compounds which are identical to amino acid sequence that are synthesized by organizm, which can interact with growth factor receptors and provide antiaging clinical effect. The aim of the study. Investigation …
Introduction. The study of growth factors in tissues of various kinds of nevi alongside with the skin melanoma can provide valuable information about the pathogenesis of the latter, determine the factors of early diagnostics of melanoma, as well as outline the…