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Molecular Medicine Peer-reviewed scientific journal

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 3–9

Sirtuin expression in skin fibroblasts: pharmacomodulatory effect of quercetin

Introduction. Sirtuins (SIRTs) are NAD+-dependent histone deacetylases involved in the intracellular regulation of multiple biological processes including DNA repair, autophagy, inflammation, oxidative stress defence and metabolism associated with age-associat…

10.29296/24999490-2025-05-01Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2024 · pp. 52–60

Molecular mechanisms of the geroprotective action of magnesium hyaluronan in inflamaging human skin fibroblasts

Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins …

10.29296/24999490-2024-06-06Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 32–37

AED PEPTIDE ACTIVATES GENE EXPRESSION AND DIFFERENTIATION PROTEINS SYNTHESISOF HUMAN SKIN FIBROBLASTS DURING REPLICATIVE AGING

The aim of this work is to study the effect of the AED peptide on fibroblast differentiation of human skin when aging in vitro. Methods. The study was conducted on DF-1 cell line (human dermal fibroblasts (mesenchymal stem cells)) isolated from the skin of the…

10.29296/24999490-2022-02-05Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2019

MOLECULAR MECHANISMS OF RETARDATION OF SKIN AGING UNDER INFLUENCE 0F HUMAN PLACENTA HYDROLYSATE

Introduction. Application of placenta hydrolysate in cosmetology opens a new page in anti-aging therapy. Numerous studies have confirmed the antioxidant, anti-inflammatory, anti-pigmental properties of placenta hydrolysate preparations, as well as activation o…

10.29296/24999490-2019-02-07Details ↗
Research article2012

INTRODUCTION OF MODIFIED mRNA hTERT, CAUSES SHORT-TERMTELOMERASE ACTIVITY IN HUMAN SKIN FIBROBLASTS

Reprogramming of human cells without genetic modification is increasingly used technology in experimental cell biology. One of these promising methods is the transfection of synthesized mRNA of transcription factors. In this study we synthesized a modified mRN…

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