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Molecular Medicine
Found: 10
Introduction. Sirtuins (SIRTs) are NAD+-dependent histone deacetylases involved in the intracellular regulation of multiple biological processes including DNA repair, autophagy, inflammation, oxidative stress defence and metabolism associated with age-associat…
Introduction: Biorevitalization is a modern method of injection cosmetology aimed at correcting age-related skin changes by introducing hyaluronic acid (HA) and additional biologically active components. The hyaluronic gel for microimplantation and mesotherapy…
Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins …
Introduction. An experimental study of the pathogenetic mechanisms of the development of inflammatory-destructive changes in the joints in animal models was carried out in order to develop new diagnostic strategies for further implementation of the results obt…
The review considers the role of hyaluronic acid (HA), primarily low-molecular-weight fractions of HA, in the regulation of the cell cycle of tumor cells. The formation of a pool of low-molecular weight HA molecules is due to the high activity of hyaluronidase…
Introduction. The decline in collagen I type synthesis and the gain in matrix metalloproteinases (MMPs) activity are the main characteristics of the molecular skin aging. MMPs are ferments which cleave collagen. The aim of the study was to investigate the infl…
Introduction. Hyaluronic acid in combination with other biology active molecules and ions is an efficient drug for the function restoration and normalizing an external appearance of the skin during aging. However, the comparative investigation of hyaluronic ac…
The review considers the system of hyaluronic acid (HA), represented by its receptors, the enzymes of synthesis (hyaluronan synthase), cleavage (hyaluronidase). The participation of the HA system in the regulation of the cell cycle was demonstrated. The most i…
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
Purpose an experimental evaluation of the effectiveness of new hydrogels based on hyaluronic acid and chitosan succinate as an agent of mitomycin C (MMC) for glaucoma surgery. Material and methods. Synthesis of hydrogel drainage (HD): The required amount of MM…