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Molecular Medicine
Found: 20
Introduction. Cerebrovascular diseases are a heterogeneous group of conditions shaped by the interaction of polygenic susceptibility, rare monogenic variants, vascular remodeling, neuroinflammation, dysregulated hemostasis, and epigenetic reprogramming. Recent…
Introduction. Arterial hypertension (AH) and obesity form a common cardiometabolic phenotype, in which hemodynamic overload, dysfunctional adipose tissue, estrogen deficiency, dyslipidemia, endothelial dysfunction, vascular remodeling, and electrophysiological…
Metabolic syndrome (MS) is a cluster of conditions including abdominal obesity, hypertension, dyslipidemia, and hyperglycemia that are very common in developed countries. The prevalence of MS increases annually. In recent years, a significant increase in the p…
Relevance. Poor blood pressure control remains a leading cause of cardiovascular morbidity and mortality worldwide. Despite the fact that today information is actively accumulating about various genetic markers as predictors of many diseases, information about…
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. An important task in cardiology is the search and study of new biomarkers. Scientific interest is actively focused on the study of interleukin-11 (IL-11). The purpose of the literature…
Introduction: Great progress has been made in the treatment of arterial hypertension (AH). However, despite the fact that new technologies have paved the way for practical medicine, the number of deaths and disabilities from diseases of the cardiovascular syst…
Cellular senescence is a reaction of cells to damage, which consists in a full stop of the cell cycle, changes of the signaling pathways and secretory activity associated with aging. Regardless the inducing factor, cellular aging of different types have a simi…
Cardiomyopathies are diseases that affect the heart muscle. They are characterized by myocardial dysfunction in the absence or low severity of common cardiovascular diseases, such as coronary atherosclerosis, hypertension, valvular heart diseases. Cardiomyopat…
Cardiovascular diseases (CVD) are considered to be one of the leading causes of lethality in patients of older age groups. In the last decade, the issue of finding a material for effective non-invasive diagnosis of CVD has become urgent. The review considers t…
The neuropeptide galanin (Gal) is widely distributed as well in central and peripheral nervous system, as in other organs and tissues of humans and animals. Its pleotropic effect is due to an activation or inhibition of galanin specific receptors – GalR1, GalR…
In the presented review a new potential risk factor for atherosclerosis and cardiovascular disease such as microflora of the human gastrointestinal tract is considered. The modern concept of lipid metabolism and its effects on human health outlining the basic …
Preeclampsia is the pregnancy complication characterized by the presence of arterial hypertension and proteinuria. Preeclampsia is the leading cause of maternal and perinatal morbidity and mortality. To date, there are more than 40 advanced theories of etiopat…
The aim of this work was to study the relationship between adiponectin gene polymorphisms G276T with obesity and obesity-related diseases in the Kyrgyz population. Material and methods. We genotyped 288 Kyrgyz subjects (143 women and 145 men; age range: 30–75 …
Introduction. Chemokines are a group of proteins that plays an active role in the regulation of the vascular wall inflammation during the development of essential hypertension. The aim of the study was to investigate an association between essential hypertensi…
The etiologic factors, features of pathogenesis and pathomorphology of thoracic and abdominal aortic aneurysms are considered in review. The morphologic and biologic features of the wall of thoracic aneurysms in Marfan's disease, Ehlers-Danlos, Loeys-Dietz, Tu…
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…
Introduction. To date, the mechanisms underlying the majority of cardiac arrhythmias are unclear. The disturbance of sympathetic innervation of the heart may be as well the cause of atrial fibrillation (AF), as the reason of myocardial dysfunction of the left …
Introduction. Despite the fact that portal hypertensive gastropathy (PHG) developing in patients with portal hypertension (PH) is a serious clinical problem, its pathogenesis remains to be poorly studied. The aim of our research was to study the proapoptotic p…
Introduction. In recent years among non-drug methods of treatment and rehabilitation of patients of elderly and senile age is a promising application of low-intensity millimeter waves as an important reserve of increasing the effectiveness of the complex thera…
The article presents results of a comparison of clinical, genealogical and molecular genetic data of the study of the role of gene polymorphisms of renin - angiotensin system (REN (G83A), AGT (M235T), AGTR1 (A1166C)) in children with hypertension, with taking …