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TRANSLATIONAL AND POST-TRANSLATIONALREGULATION OF ACTIVITY OF HIF-1 IN HYPOXIA AND ISCHEMIA

Ruzaeva V.A., Boitsova E.B., Salmina A.B.

This review covers current concepts on the structure, function, regulation of translation and post-translational modifications of hypoxiainducible factor 1 (HIF-1). In addition, the role of this transcription factor in hypoxia and ischemia is discussed. We foc…