ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 3–9
Kryukova V.V., Tsepelev V.L., Tereshkov P.P.
The study of immune checkpoint expression by tumor microenvironment T-lymphocytes is necessary for understanding the pathophysiological mechanisms of tumor immunosuppression, as well as for the development of new methods of targeted therapy for colorectal canc…
ОБЗОР2024 · pp. 3–12
Bueverova E.L., Zolnikova O.Yu., Paltzev M.A.
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The specificity of the immune microenvironment of an organ limits the possibilities of traditional therapeutic and surgical approaches to treatment, therefore one of the mo…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2022 · pp. 25–32
Gershtein E.S., Kuzmin Yu.B., Alferov A.A., Korotkova E.A., Tsarapaev P.V., Sokolov N.Yu., Kuznetsov I.N., Vashketova O.I., Kozlova E.M., Yanushevich O.O., Boulytcheva I.V., Stilidi I.S., Kushlinskii N.E.
Background. Low sensitivity of bone tumors to various schemes of standard chemotherapy stimulated the search of new targets for their medicamentous treatment. Among such targets are the so-called “immune checkpoints” promoting the escape of the tumor from the …