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Molecular Medicine
Found: 22
Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…
Introduction. A physical injury triggers a cascade of pathological processes, including the activation of the immune system and the development of local inflammation. Hereditary predisposition, pronounced structural changes, biomechanical disorders, and comorb…
The aim of this review is to systematize current knowledge on the role of selenium in biochemical processes and in the development of diseases associated with its deficiency or excess. Material and methods. A comprehensive search and analysis of publications f…
Аmphocyte production and indirectly reflect the state of the adaptive immune system. Their concentration in dried blood spots can be determined by quantitative polymerase chain reaction (qPCR). Currently, these markers are used for neonatal screening of primar…
Introduction. The significant increase in obesity among children and adolescents necessitates the search for ways to prevent and treat it. Inflammation in obesity is the main mechanism leading to comorbid changes. Aim of the study. To establish correlations be…
Alcohol consumption has a detrimental effect on human health and is associated with various pathological changes in the body. In addition to the toxic effect on various tissues and organs, ethanol and its metabolites contribute to persistent changes in the com…
Relevance. The mechanisms of B-lymphocyte immunity are not fully understood at present, in particular, the role and significance of the humoral response to viruses. There is insufficient understanding of how B-lymphocytes are selected for differentiation into …
Introduction. Studies consider the immune and neuroendocrine systems as actively interacting with each other and priority participating in the complex maintenance of homeostasis. Immune processes are dependent on the functional activity of the endocrine system…
Introduction. Recurrent pregnancy loss (RPL) is an early spontaneous termination of pregnancy before 20 weeks, which is defined as two or more miscarriages. Most of the known causes associated with the pathophysiology of RPL include endocrine disorders, antiph…
Introduction. An urgent problem in biology and medicine is the identification of biologically active molecules that affect the cellular processes of proliferation and apoptosis in various tissues of the body. Purpose of the study. The purpose of this study was…
Introduction. The effectiveness of antitumor immunity is determined by various mechanisms of recognition of tumor antigens, while the diversity of the repertoire of antigenic receptors is determined by V(D)J recombinations in maturing T and B cells. The aim of…
Introduction. Primary immunodeficiency (PID) is a congenital disorder of the immune system that causes severe, chronic, autoimmune, infectious and oncological diseases with untimely diagnosis and treatment. Given that PIDs often do not have specific clinical m…
Relevance: The review is devoted to the analyses of literature data on disorders of the immune system in COVID-19. Since some of the clinical symptoms of COVID-19 are consistent with those of autoimmune diseases, one of the fundamental questions about COVID-19…
Recently, the involvement of histamine in the regulation of the function of cells in the immune system has been actively studied, including the ability of the mediator to modulate inflammatory responses of different cell types to infectious agents by activatin…
The purpose of this review is a systematic analysis of data from clinical observations, international experience, and reviews related to the pathogenetic aspects of the impact of a new coronavirus infection on the blood system. Information was searched in MedL…
The review article discusses the principles of a personalized approach to changing the functional activity of the immune system based on micronutrients. The activity of the immune cells has been demonstrated to depend on the level of supplied not only macro- b…
Introduction. Neuroglia plays an important role in maintaining the stable functioning of the CNS. Of particular importance are neuroglial cells in the organization of the immune system of the brain, activating both with physical, physiological damage, and with…
This article provides a modern analysis of the literature on the mechanisms of activation of mast cells (MC) because they are regulatory cells that make up an important part of the immune system and are part of the first line of defense against various patholo…
Introduction. The incidence of infectious and inflammatory diseases, including sepsis, increases with the age, which is explained by the age-related decrease in the content of sex steroids. However, the features of the course of systemic inflammatory responses…
Introduction. Low rate of the pregnancy frequency in the IVF programs is one of the challenges in gynaecology nowadays. One of the approaches to enhance the efficacy of the assisted reproductive technology is to estimate the success of the forthcoming procedur…