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Molecular Medicine
Found: 18
Introduction. Cerebrovascular diseases are a heterogeneous group of conditions shaped by the interaction of polygenic susceptibility, rare monogenic variants, vascular remodeling, neuroinflammation, dysregulated hemostasis, and epigenetic reprogramming. Recent…
The aim of the study. To describe the interaction between Helicobacter pylori and Toll-like receptors, and to outline the role of TLRs gene polymorphisms in the pathogenesis of this infection. Material and methods. An analysis of publications from 2000 to 2025…
Aim of the study. The possibility of using antitumor drugs against the background of active tuberculosis is an unresolved problem of modern medicine. The aim of the experimental study was to study the course of tuberculosis infection against the background of …
Introduction. Ionizing radiation can lead to radiation damage to healthy pancreatic tissue, with the development of signs of post-radiation pancreatitis. Electron irradiation potentially has the most “sparing” effect on healthy tissue, but data on this are spa…
Introduction. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that is highly expressed in healthy lungs and performs homeostatic function there. However, the exact mechanisms of development of these diseases remain unk…
Introduction. Treatment of the coexistent pathology of lung cancer and tuberculosis remains the prerogative of experimental research, since the optimal treatment strategy for the coexistence of these two diseases has not yet been developed. The purpose was to …
Introduction. According to modern concepts, the inflammatory process is one of the key links in the development of cardiovascular, autoimmune, neurological, oncological diseases, as well as metabolic syndrome, complications of diabetes mellitus, and pathologie…
Introduction. Lung cancer and tuberculosis, make a significant affect to the morbidity and mortality of the population in Russia and in the world. Strategy of medication therapy has not been developed for cases when these diseases are combined. The aim of the …
The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmac…
Recently, the involvement of histamine in the regulation of the function of cells in the immune system has been actively studied, including the ability of the mediator to modulate inflammatory responses of different cell types to infectious agents by activatin…
Osteopontin (OPN) is a highly phosphorylated multifunctional glycosphoprotein with important functional activity in cancer and cardiovascular diseases, diabetes mellitus (DM), kidney and liver pathology, inflammatory process, and also influencing cell viabilit…
Introduction. In mammals, there are several populations of macrophages, developing from bone marrow progenitors and resident macrophages, developing from the embryonic precursors of the yolk. One of the reasons for the coexistence of several populations of mac…
Introduction. The molecular mechanisms of the development of the prostate tumor pathology are associated with the activation of both androgen-dependent and androgen-independent signaling pathways, accompanied by the development of chronic inflammation and hypo…
Introduction. In recent years, there have been aroused and actively studied mutations associated with Toll-like receptor genes (TLRs). The emerging interest is related to the identification of many associations between the TLRs polymorphism and the development…
This article provides a modern analysis of the literature on the mechanisms of activation of mast cells (MC) because they are regulatory cells that make up an important part of the immune system and are part of the first line of defense against various patholo…
Introduction. The widespread cellular technologies will sooner or later lead inevitably to the introduction of multipotent mesenchymal stromal cells (MMSC) or their exosomes to patients who have implanted artificial materials in their organism. The engraftment…
The review presents data on the role of the nuclear factor NF-κB and the von Hippel-Lindau protein (VHL) in the development of kidney cancer. Chemo- and radioresistance, specific for renal cell carcinoma, represented a significant problem in the treatment of p…
Introduction. The incidence of infectious and inflammatory diseases, including sepsis, increases with the age, which is explained by the age-related decrease in the content of sex steroids. However, the features of the course of systemic inflammatory responses…