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EXPERIMENTAL STUDY OF ANTITUMOR ACTIVITY OF NEW NITRIC OXIDE SYNTHASE INHIBITOR T1023

Filimonova M.V., Yuzhakov V.V., Shevchenko L.I., Bandurko L.N., Sevankaeva L.E., Makarchuk V.M., Chesnakova E.A., Shevchuk A.S., Tsyganova M.G., Fomina N.K., Ingel I.E., Surinova V.I.

Introduction. Activation of eNOS/sGC/cGMP-pathway is a common link in the development of angiogenic action of the majority of pro-angiogenic factors. In this regard, the chemical inhibition of NOS (Nitric Oxide Synthase) may cause a nonspecific angiostatic eff…