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Molecular Medicine Peer-reviewed scientific journal

Found: 6

ОБЗОР2025 · pp. 76–83

Synergism of ascorbic acid and RNA interferon inducers in antiviral immunity activation: molecular mechanisms and therapeutic perspectives

Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…

10.29296/24999490-2025-06-10Details ↗
ОБЗОР2023 · pp. 3–12

Imbalance of immunoregulatory molecular cellular mechanisms as a cause of recurrent miscarriage

Introduction. Recurrent pregnancy loss (RPL) is an early spontaneous termination of pregnancy before 20 weeks, which is defined as two or more miscarriages. Most of the known causes associated with the pathophysiology of RPL include endocrine disorders, antiph…

10.29296/24999490-2023-06-01Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2021

INNATE AND ADAPTIVE IMMUNITY DURING INFECTION AND IMMUNIZATION WITH INACTIVATED TICK-BORNE ENCEPHALITIS VACCINE

Introduction. Viral infections induce cellular and humoral immunity that provide virus elimination. Extracellular presentation of antigens of formaldehyde-inactivated vaccines causes mainly humoral immune response with risk of persistent infection. The aim of …

10.29296/24999490-2021-06-07Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017

ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH RISK OF CORONARY ARTERY DISEASE IN RUSSIAN POPULATION

Introduction. Atherosclerosis, manifesting itself as acute coronary syndrome, stroke, and peripheral artery disease, is a chronic progressive inflammatory disease driven by both innate and adaptive immunity. As Triggering Receptor Expressed on Myeloid Cells-1 …

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

TRANSFORMING GROWTH FACTOR-Β1,2,3 AND INTERLEUKIN-6 IN BLOOD IN PATIENTS WITH ULCERATIVE COLITIS OF VARIOUS DISEASE ACTIVITY ACCORDING TO CLINICAL PICTURE AND ENDOSCOPIC DATA

Introduction. Ulcerative colitis is a chronic inflammatory disease. Misbalance in innate and adaptive immunity including cytokines plays a significant role in its pathogenesis. Objective. To determine levels of cytokine TGFβ1, 2, 3, and IL6 in blood of patient…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015

SТIMULATION OF SIGNALING RECEPTORS GENE EXPRESSION AND INDUCTION OF SYNTHESIS OF CYTOKINES IN HUMAN BLOOD CELLS BY DRUG RIBONUCLEAT SODIUM AND ITS COMBINATION WITH INACTIVATED INFLUENZA VACCINES

Introduction. Russian drug Ribonucleate sodium (mixture of yeast ssRNA and dsRNA) possesses of the wide spectrum of antiviral and immunomodulation actions, it improves the efficacy of inactivated vaccines in experimental animals. It can activate IFN-system gen…

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