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Molecular Medicine
Found: 10
Introduction. An actual decision of the issue of safety and effective drug therapy improvement is the development of transport systems that allow to provide targeted delivery of drugs to target cells, while reducing their toxic effects. The aim of the work was…
Introduction. An increase in the number of patients with atopic dermatitis (AD) among pregnant women is recorded annually. However, the pathogenesis of AD during pregnancy is not fully understood. Exacerbations of AD during pregnancy require in-depth study, si…
Introduction. Under the influence of glioma cells, peritumoral zone astrocytes may acquire tumorigenic phenotype, particularly due to the suppression of immunocompetent cells. The aim of the study. Investigate the changes in the gene expression profile of glio…
Introduction. In mammals, there are several populations of macrophages, developing from bone marrow progenitors and resident macrophages, developing from the embryonic precursors of the yolk. One of the reasons for the coexistence of several populations of mac…
Introduction. Valvular calcification precedes the development of valvular stenosis. Currently, there being no way to effectively prevent the valvular heart disease progression, and valve replacement remains to be the only treatment option. Aim. To investigate …
Abstract sources: PubMed, WINITI RAS, Embase, Web of Science, Cochrane database, Current Controlled Trials for information about associations of polymorphism of genes cytokines (IL6, TNFα, IL10, TGFβ) with atherosclerosis and its complications are analyzed. As…
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…
Introduction. According to inflammatory theory of atherosclerosis the immune damage of arteries with an autoimmune component – is the main link of its pathogenesis. The imbalance of cytokines production influences on course and prognosis of atherosclerosis. As…
Introduction. Disorders in anti-TB immunity may be formed at the stage of interaction between antigen-presenting cells and T-lymphocytes by means of cytokines and their receptors. The key cytokines of T-lymphocyte activation are interleukins (IL) of the IL12 f…
The purpose of this study was to determine the influence of transcardial perfusion, as well as social hierarchy in male mice, on the level of gene expression in the cerebral cortex of mice using the example of the proinflammatory cytokine IL-1β. Material and m…