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Integrative role of biomarkers and trace element profiles in risk assessment and stratification of metabolic syndrome in gastroenterology patients

Bystrova V.I., Shrayner E.V., Lifshits G.I., Kudlay D.A.

Metabolic syndrome (MS) is a cluster of conditions including abdominal obesity, hypertension, dyslipidemia, and hyperglycemia that are very common in developed countries. The prevalence of MS increases annually. In recent years, a significant increase in the p…

The Impact of Low Doses of Ethanol on the Taxonomic Composition and Biodiversity of the Microbiota in the Small and Large Intestines of C57Bl6 mice

Laskina T.A., Zabolotneva A.A., Kharchev D.N., Shestopalov A.V.

Alcohol consumption has a detrimental effect on human health and is associated with various pathological changes in the body. In addition to the toxic effect on various tissues and organs, ethanol and its metabolites contribute to persistent changes in the com…

Biomarkers of oxidative stress and proteopathies in the diagnosis of neurodegenerative diseases

Mikashinovich Z.I., Telesmanich N.R., Smirnova O.B., Chernogubova E.A.

Introduction. Despite numerous studies in the field of neurodegenerative diseases, the exact mechanisms of these processes have not yet been identified. The purpose of this review is to analyze the methodological approaches necessary to revise the traditional …

THE GUT MICROBIOTA IS THE MISSING LINK IN THE PATHOGENESIS OF CELIAC DISEASE

Bueverova E.L., Zolnikova O.Yu., Dzhakhaya N.L.

Results. During the analysis of the published pathogenesis of celiac disease (CD) is actively discussed. It is assumed that the change in gluten tolerance is formed under the influence of a number of different factors, including genetic predisposition and envi…

THE ROLE OF THE INTESTINAL MICROBIOTA IN THE PATHOGENESIS OF BRONCHIAL ASTHMA

Potskherashvili N.D., Zolnikova O.Yu., Ivashkin V.T.

It is currently being discussed that the microbiota of the gastrointestinal tract and its metabolites affect the course of bronchial asthma (BA). The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of ВА. Ma…

INTESTINAL MICROBIOTA IN THE PATHOGENESIS OF CHRONIC HEART FAILURE

The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of CHF. Material and methods. A analysis of the main foreign and domestic sources on PubMed, MedLine, eLIBRARY databases over the last 20 years has been ca…

PROTEOMIC PROFILING OF ESCHERICHIA COLI, ISOLATED FROM CROHN’S DISEASE PATIENTS

Matyushkina D.S., Pobeguts O.V., Bukato O.N., Rakitina D.V., Baikova Yu.P., Ladygina V.G., Andreev D.N., Maev I.V., Scherbakov P.L., Govorun V.M.

Introduction. A possible pathogenesis for Crohn’s disease (CD) involves the provocation of uncontrollable immune response by intestinal microbiota. Escherichia coli is regarded as a candidate for possible pathogen, since its content is increased in intestine o…