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Digital twin of early immunometabolic response after tick bite. LC-MS/MS profiling of lipid mediators and the kynurenine pathway in a QSP model of systemic inflammation

Kutsenko V.P., Nosov A.V., Ushal I.E., Seliverstov P.V., Papina E.I., Chopalaeva A.G., Nuritdinova A.F., Isupov I.I.

Tick bite is traditionally viewed in clinical practice primarily as an event associated with the risk of pathogen transmission. Although this interpretation is epidemiologically justified, it does not capture the molecular layer that develops within the first …