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DECREASE IN ANG AND VEGF mRNA LEVELS DURING PROGRESSIVE ANGIOGENESISOF THE LIVER VENOUS SYSTEM OF WISTAR RATS IN EXPERIMENTAL CIRRHOSIS

Introduction. Currently, understanding the molecular mechanisms of pathological angiogenesis remains a fundamental problem in hepatology. The aim of this work was to find a relationship between the level of mRNA expression of the ang, vegf genes and angiogenes…

Alterations in mRNA expression of rat astrocytes co-cultured with c6 glioma cells and impact of glioma-conditioned astrocytes on dendritic cell maturation

Chernysheva A.A., Chekhonin I.V., Sosnovtseva A.O., Cherepanov S.A., Kardashova K.Sh., Gurina O.I., Silantyev A.S., Pavlova S.A., Pavlova G.V., Savelieva T.A., Loshhenov V.B., Chekhonin V.P.

Introduction. Under the influence of glioma cells, peritumoral zone astrocytes may acquire tumorigenic phenotype, particularly due to the suppression of immunocompetent cells. The aim of the study. Investigate the changes in the gene expression profile of glio…

Features of local expression of mRNA, IL-1β, IL-18, CCL2/MCP-1 in modeling pigment epithelium atrophy and retinal degeneration in the experiment on rabbits

Neroev V.V., Balatskaya N.V., Svetlova E.V., Neroeva N.V., Ryabina M.V., Karmokova A.G., Losanova O.A., Chernomorets I.Yu., Ilyukhin P.A.

Introduction. Degenerative retinal diseases are considered as the leading cause of blindness and low vision worldwide. The last studies have provided convincing evidence of the involvement of immunological factors in the development and progression of the dise…

THE PROFILES OF LACTOBACILLLUS MICROFLORA AND LOCAL IMMUNE RESPONSE OF THE VAGINAL MUCOSA IN THE DIAGNOSIS OF VAGINAL INFECTIONS

Budilovskaya O.V., Krysanova A.A., Shipitsyna E.V., Perever- zeva N.A., Vorobyova N.E., Gerasimova E.N., Grigoryev A.N., Savi- cheva A.M.

Introduction. In vaginal infections, both microbial factor and the state of local (mucosal) immunity, determined by the immunological reactivity of the macroorganism, play an important role in the pathogenesis of an infectious process. Aim of the studying. To …

PROGNOSTIC SIGNIFICANCE EXPRESSION OF MRNA TOP1, TOP2Α, TUBΒ3, TYMS, ABCC5 AND GSTP1 GENES IN PATIENTS WITH NON-SMALL CELL LUNG CANCER

Deryusheva I.V., Tsyganov M.M., Rodionov E.O., Efteev L.A., Ibragimova M.K., Miller S.V., Tuzikov S.A., Litviakov N.V.

Introduction. Despite the continuous improvement of the surgical method of treatment of patients with non-small cell lung cancer (NSCLC), there is no noticeable tendency to improve survival data. This 5-year index does not exceed 15–25%. In this regard, it is …

THE ROLE OF P53 AND NOXA IN THE PATHOGENESIS OF EARLY MISCARRIAGES

Lebedeva O.P., Zhukova I.O., Ivashova O.N., Pakhomov S.P., Churnosov M.I.

Introduction. Missed and spontaneous abortions are one of the most important causes of the reproductive loss. The aim of the study: to study specialties of mRNA expression of p53 and proteins of its signaling pathway in the decidual tissue at 6–10 weeks of ges…

THE ROLE OF ANTIMICROBIAL PEPTIDES IN SHAPING OF MICROBIOCENOSIS OF FEMALE REPRODUCTIVE TRACT AT LATE PREGNANCY

Lebedeva O.P., Pakhomov S.P., Yakovleva O.N., Churnosov M.I., Kalutsky P.V., Tafintseva G.A., Golovchenko O.V., Nagorny A.V.

Introduction. Antimicrobial peptides (AMPs) are molecules of small dimensions, consisting of about 30–40 amino acids, possessing of antiviral, antibacterial and fungicidal action. AMPs can be considered as a first barrier against pathogens in genital tract. Th…

SOME TISSUE MARKERS AND MULTIGENE SIGNATURES OF BREAST CANCER: PROGNOSIS AND DETERMINATION OF DRUG SENSITIVITY

Guens G.P.

Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…