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Molecular Medicine
Found: 8
Introduction. Immune checkpoint (IC) signaling pathways are involved in regulating the functions of T lymphocytes and NK cells, which play a key role in antitumor and antiviral control. The purpose of our study was to systematically analyze the information pre…
Background. Genotyping of the tumor samples is necessary for a personalized approach in the treatment of patients with malignancies. The identification of somatic mutations in EGFR and KRAS genes can help to predict the course of the disease and to individuali…
Introduction. Her2/neu is one of the most studied molecular target the overexpression of which is associated with poor prognosis and aggressive course of the disease. The use of modern non-invasive radionuclide techniques with the application of highly affinit…
Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of h…
Introduction. Mutations in the tumor suppressor gene TP53 are observed approximately in the half of all human malignancies. In bladder cancer (BC), ТР53 molecular alterations were shown to be associated with more aggressive tumor phenotype; however their clini…
Among oncology diseases the primary bone tumors make up to 0,7–2,0% of all malignancies. The peak of morbidity caused by bone tumors falls on the age of person’s social activity. Bone tumors are one of the most aggressive among malignant human tumors. That’s w…
Introduction. Breast cancer pathogenesis is associated with alterations in processes of regulating of IGF effects and also in IGF-signaling pathway activation. The direct correlation between high IGF blood serum levels and the rescue of malignancies in prostat…
The prognosis of one of the most commonly occurring malignancies worldwide – colorectal cancer (CRC) – depends on the development of disease recurrence and distant metastases, most frequently detected in the liver. The aim of our research was to study the asso…