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Molecular Medicine
Found: 33
Introduction. Posttraumatic stress disorder (PTSD) is presented as a systemic multilevel metabolic-immuno-psycho-neurological disorder with genetic predisposition and epigenetic influences, which radically changes the approach to its understanding and treatmen…
Introduction. Thanks to advances in modern medicine, it has been possible to significantly increase life expectancy. With the high effectiveness of methods for diagnosing and treating many chronic pathologies, a sharp increase in the number of elderly patients…
Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins …
Relevance. Ectopic secretion, which occurs in the early stages of tumor development, is not only one of the first signs of a neoplasm, but can also indicate the severity of the oncological process. Purpose of the study: To evaluate the possibility of using the…
Introduction. Sepsis is multiple organ dysfunction in response to the generalization of an infectious process. The likelihood of developing sepsis correlates with the value of biochemical parameters, which can serve as prognostic markers. The endothelium, as t…
Despite significant advance in clear cell renal cell carcinoma treatment, immune checkpoint inhibitors (ICIs) still have limited therapeutic efficacy. Taking into account the resistance to immunotherapy, observed in malignant neoplasms, the search for predicti…
Introduction. The search for molecular markers of adverse treatment outcomes in individuals with pulmonary tuberculosis (PT) is relevant due to the worldwide increase in drug resistance of Mycobacterium tuberculosis (MBT) strains to anti-tuberculosis drugs (PT…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the development of ferroptosis; the main conditions for the development of this type of cell death are described, and cell markers and targets for the induction of ferropto…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the …
Introduction. In 2013 The Cancer Genome Atlas research group divided the molecular aberrations in endometrial cancer into four subtypes: POLE mutations, microsatellite instability, copy-number low and copy-number high. These subtypes have different prognosis a…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the pathogenesis of sarcoidosis, it describes the signaling molecules involved in the development of sarcoidosis, which can be biomarkers and targets for optimizing persona…
Introduction. Buccal epithelium (BE), in which cells the expression of signal molecules reflecting the state of homeostasis of the body in normal and pathological conditions is verified, is used as a diagnostic material for a number of diseases in adults. The …
Introduction. The molecular mechanisms of the development of tumor pathology of the thyroid gland are associated with the activation of angiogenesis and the development of hypoxia, which contributes to the proliferation, invasion, and progression of the diseas…
Personalized medicine implements new methods of molecular diagnostic for increasing the efficacy of the treatment of patients and the verification of the liability to diseases. Thus the search, development and applying modern methods and technologies of biomed…
The review highlights current data on molecular pathogenesis and potential markers of clear cell renal cell carcinoma, obtained in MultiOmyx studies. Key molecular mechanisms of the pathogenesis of RCC are the loss of functions of the VHL, PBRM1, SETD2, BAP1, …
Introduction. The search of molecular markers for early diagnostics, prognosis, and identification of new objects for molecular-targeted therapy of primary bone tumors remains one of the most important tasks despite the significant achievements in the treatmen…
The prostate cancer (PCa) incidence rate rises steadily among males all over the world. Over the past twenty years, the prostate-specific antigen (PSA) definition level in the patient's blood has been used for the PCa non-invasive diagnostics. However, due to …
Introduction. Fibroadenomatosis (FAM) is a heterogeneous group of pathological conditions of the mo-Nochnoi gland, with hormone-dependent nature and different degree of risk maligni of the organization. The use of routine histological stains is not enough to d…
Introduction. Recent reports have demonstrated patients with malignant neoplasias have different molecular genetic aberrations. But there are few data available concerning patients with multiple primary tumors (MPT). Aim. To study molecular genetic alterations…
Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diag…