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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

QUANTIFICATION OF THE NUMBER OF MITOCHONDRIAL DNA COPIES IN HUMAN OOCYTES WITH DIFFERENT MORPHOLOGICAL ABNORMALITIES

Syrkasheva A.G., Krasny A.M., Mayorova T.D., Makarova N.P., Dolgushina N.V.

Introduction. In IVF-cycles ≈70% of human oocytes have different morphological abnormalities (dysmorphisms). Embryos from dysmorhic oocytes may have delay in development due to mitochondrial dysfunction and disorders of energy accumulation in the cell. The aim…

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Research article2013

GENOTOXIC EVENTS AND DISEASES

Durnev A.D., Zhanataev A.K., Shreder O.V., Seredenina V.S.

Based on literature and own data the role of genotoxic events in nosogenesis of hereditary, congenital and somatic diseases is considered. Special emphasis is paid to the analysis of significance of premutagenic DNA lesions and as well induced gene mutations i…

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