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FREQUENCY AND SPECTRUM OF KRAS GENE MUTATIONS IN ADVANCED COLORECTAL CANCER. CLINICAL AND MORPHOLOGICAL CHARACTERISTICS

Kit O.I., Gevorkyan Yu.A., Soldatkina N.V., Vodolazhsky D.I.

Introduction. KRAS mutations play a critical role in human tumorigenesis and are the most prevalent in colorectal cancer. Because KRAS is the most frequently mutated factor downstream of the EGFR signaling pathway, it was considered to be a candidate molecular…