Found: 26
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2026 · pp. 10–21
Seliverstov P.V., Salikova S.P., Aleshko O.V., Simakhodsky A.S., Shapovalov V.V., Dyakov T.S., Romakh D.V., Roslyakova M.A., Chernyakova V.E., Golikova D.A.
Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…
ОБЗОР2025 · pp. 93–100
Deeva T.A., Tyagunov E.G., Zolnikova O.Yu.
The aim of this review is to systematize current knowledge on the role of selenium in biochemical processes and in the development of diseases associated with its deficiency or excess. Material and methods. A comprehensive search and analysis of publications f…
ОБЗОР2025 · pp. 55–63
Evert L.S., Potupchik T.V., Saranchina Yu.V., Khadzieva M.K., Samoyavcheva V.S., Tsalikova R.R.
Introduction. Neurotoxicity is a common complication of chemotherapy that negatively affects the quality of life of cancer patients. Damage to the nervous system affects both the peripheral nerves (peripheral neuropathy) and the central nervous system (chemo b…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 38–44
Temezhnikov S.A., Belitskaya E.D., Makarenko V.Yu., Dubinkin I.A., Kuzmin E.A., Pokidova K.S., Piavchenko G.A., Zalygin A.V., Kuznetsov S.L.
Introduction. Heat shock proteins (HSPs) are a group of highly prospective compounds that can be used in various branches of clinical medicine, such as neurology, pharmacology and oncology. Studying the content of these proteins in various parts of the brain o…
ОБЗОР2025 · pp. 21–31
Evert L.S., Potupchik T.V., Veselova O.F., Svetlakova I.S., Panchenko B.A., Kudasheva R.R., Melnikova A.N.
Objective. To analyze the potential risks and technological limitations of using genome editing methods in neurodegenerative diseases, as well as to assess the prospects for their implementation in clinical practice. Material and methods. A systematic analysis…
ОБЗОР2025 · pp. 3–11
Kokhanov A.V., Bisalieva R.A., Ebzeeva L.Kh.
Introduction. This review is devoted to the study of the structure, properties, evolution of hemoglobins, biochemical and clinical aspects of the use of neuroglobin (Ngb) and fetal hemoglobin (HbF) in health and in ischemic hypoxia of the brain. Material and m…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2025 · pp. 56–64
Mitrofanova L.B., Makarov I.A., Guseva K.A., Danilova I.A., Gulyaev D.A.
Introduction. The pathogenesis of infection of the central nervous system (CNS) with SARS-CoV2 and nervourological complications are still poorly understood, as well as the link of viral infection with the risk and the course of gliomas. The aim. Evaluating of…
ОБЗОР2025 · pp. 16–26
Tereshchenko S.Yu., Potupchik T.V., Evert L.S., Alieva L.G., Kozyrina Y.E., Maremkulov A.A.
Objective. To analyze the current state of preclinical and clinical studies in genome editing for neurodegenerative diseases, evaluate its potential impact on clinical practice, and examine ethical aspects of these technologies’ application. Material and metho…
ОБЗОР2024 · pp. 29–39
Tereshchenko C.Yu., Potupchik T.V., Evert L.S., Kovalchuk V.A., Filippova M.A., Magalova A.R.
The purpose of this review is to analyze current advances in the field of genome editing, their application for the modeling and treatment of neurodegenerative diseases, as well as to discuss current limitations and prospects for overcoming barriers in clinica…
ОБЗОР2024 · pp. 3–13
Kudlay D.A., Filimonov D.A., Morozov V.V., Ishchenko R.V., Eresko A.B., Trubnikova N.N., Belotserkovskaya M.A., Kisilenko I.A., Nosova I.N.
Background. During the last decades, data on potential cytoprotective effects of decarboxylated and deiodinated endogenous compounds – metabolites of thyroid hormones, constituting the thyronome, have been accumulated. The aim of this review is to systematize …
ОБЗОР2023 · pp. 34–39
Yasenyavskaya A.L., Tsibizova A.A., Samotrueva M.A.
Introduction. The review is devoted to the analysis of modern concepts of the neurodegenerative properties of depression. Depression is now regarded as the most common mental illness with significant social consequences. The aim of the study is to determine th…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2023 · pp. 53–59
Shestopalov A.V., Davydov V.V., Tumanyan G.T., Savchuk D.V., Teplyakova E.D., Shin V.F., Grigorieva T.V., Laikov A.V., Borisenko O.V., Roumiantsev S.A.
Introduction. There is take place increasing in the incidence of obesity among children and adolescents in the world. However, until now there are not exist clear views about mechanisms of that phenomenon. The aim of study. The purpose of that work is comparat…
ОБЗОР2022 · pp. 18–27
Kuznik B.I., Guseva E.S., Davidov S.O., Chalisova N.I.
Aim of investigation. The study of characteristics of fibroblast growth factors (FGFs), as a man factor FGFd, including 22 structurally connected polypeptides, is necessary for the neuroprotection by the CNS degenerative pathology is presented playing a great …
ОБЗОР2021
Mashkovtseva E.V., Nartsissov Ya.R.
The purpose of this review was to describe information about the etiology and pathogenesis of the main manifestations in patients with coronavirus infection COVID-19 and the molecular mechanisms of the possible use of metabolite drugs. Material and methods. Th…
ОБЗОР2021
Pavlova O.V., Pavlov K.A., Murashko A.A., Gurina O.I., Shmukler A.B.
Little is known about the etiology of neuropsychiatric disorders. Glutamate-mediated excitotoxicity is one of the main pathological mechanisms occurring in various types of acute and chronic diseases of the central nervous system. Glutamate is the major excita…
ОБЗОР2020
Nozdrachev A.D., Goryukhina O.A., Martyushin S.V., Mishchenko I.V.
The prospect of developing transport systems using histones for delivery of therapeutic agents possessing poor penetration characteristics through cellular membranes and tissue barriers has been investigated. A review of the literary, as well as proper data, a…
ОБЗОР2020
Mironova E.S., Linkova N.S., Popovich I.G.
Neurodegenerative diseases are a group of pathologies of the nervous system, which are characterized by progressive death of nerve cells and gradually increasing atrophy of the corresponding parts of the brain or spinal cord. In developed countries, an increas…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2020
Ivkin D.Yu., Sukhanov D.S., Plisko G.A., Ivkina A.S., Krasnova M.V., Titovich I.A., Semivelichenko E.D., Stepanova I.L., Il’nickij V.P., Karpov A.A., Okovityy S.V., Karshin A.V.
Introduction. The pathological state of hypoxia of the body occurs with an inadequate supply of tissues and organs with oxygen or with a violation of its utilization in the process of biological oxidation. Ethylmethylhydroxypyridine has a multi-component mecha…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2020
Chalisova N.I., Lopatina N.G., Kamishev N.G., Zachepilo T.G.
Introduction. The investigation of biologic active substances, correcting the morphologic and functional characteristics of tissue changes, is an actual medicine task by the pathology therapy. Purpose of the study was the investigation of tetrapeptide AEDG eff…
ОБЗОР2019
Arutjunyan A.V., Milyutina Yu.P., Zalozniaia I.V., Shcherbitskaia A.D., Kerkeshko G.O.
This review article focuses on modern ideas about the role of neurotrophic factors (BDNF, NGF, NRG1, etc.) in the formation of the placenta and their impact on the development of the fetal nervous system in early ontogenesis. Data on the common effect of neuro…