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Molecular Medicine
Found: 7
Objective. To systematize current knowledge on the structural organization, conformational dynamics, and mechanisms of membrane toxicity of alpha-synuclein, as well as to analyze the role of age-associated impairment of proteostasis systems in the pathogenesis…
Introduction. Post-transcriptional and post-translational modifications of the alpha-synuclein protein are considered important links in the pathogenesis of Parkinson’s disease (PD) and multiple system atrophy (MSA). Regulation of mRNA stability and translatio…
Introduction. Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder, the primary pathological feature of which is the death of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of aggregated α-synuclein. Th…
Introduction. Heat shock proteins (HSPs) are a group of highly prospective compounds that can be used in various branches of clinical medicine, such as neurology, pharmacology and oncology. Studying the content of these proteins in various parts of the brain o…
Introduction. Trace elements are widely involved in various metabolic processes in humans, including thyroid hormones. Iodine is a part of thyroid hormones, is actively involved in the work of thyroid enzymes, copper, zinc and manganese are included in the com…
Anti-glutamate decarboxylase (GAD65 isoform) autoantibodies are present in the blood of patients with such various autoimmune disorders, as diabetes type I, as well as relatively rare neurological diseases, such as Stiff Person syndrome and cerebellar ataxia. …
Schizophrenia is a severe psychiatric disorder with etiology not clearly determined yet. Scientists associate its development with various factors including excessive expression of some genes and unstable social environment. The World Health Organization estim…