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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

ASSOCIATION BETWEEN XRCC1 ARG399GLN AND P53 ARG72PRO POLYMORPHIC MARKERS AND THE RISK OF BREAST CANCER RISK IN KYRGYZ WOMEN

Isakova Zh.T., Talaibekova E.T., Makieva K.B., Asambaeva D.A., Sultangazieva B.B., Aldashev A.A.

Aim. To investigate the possible association between XRCC1 Arg399Gln and p53 Arg72Pro polymorphism and the risk of breast cancer (BC) risk in Kyrgyz women. Methods. The XRCC1 Arg399Gln and p53 Arg72Pro genotypes were determined with the use of the polymerase c…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015

ТР53 GENE MUTATIONS AND THEIR PROGNOSTIC SIGNIFICANCE IN BLADDER CANCER

Smal M.P., Rolevich A.I., Nabebina T.I., Krasny S.A., Goncharova R.I.

Introduction. Mutations in the tumor suppressor gene TP53 are observed approximately in the half of all human malignancies. In bladder cancer (BC), ТР53 molecular alterations were shown to be associated with more aggressive tumor phenotype; however their clini…

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