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Molecular Medicine
Found: 128
Introduction. Cerebrovascular diseases are a heterogeneous group of conditions shaped by the interaction of polygenic susceptibility, rare monogenic variants, vascular remodeling, neuroinflammation, dysregulated hemostasis, and epigenetic reprogramming. Recent…
Introduction. Microglia initiate and play a key role in neuroinflammation, which is currently considered one of the main mechanisms of neurodegeneration in Alzheimer’s disease. The aim of this study was to analyze the morphofunctional characteristics of microg…
Objective. To investigate the role of toxic metabolites of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) in autism spectrum disorders (ASD) pathogenesis and their relationship with intestinal dysbiosis. Material and methods. The study included…
Metabolic syndrome (MS) is a cluster of conditions including abdominal obesity, hypertension, dyslipidemia, and hyperglycemia that are very common in developed countries. The prevalence of MS increases annually. In recent years, a significant increase in the p…
Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…
Introduction. A physical injury triggers a cascade of pathological processes, including the activation of the immune system and the development of local inflammation. Hereditary predisposition, pronounced structural changes, biomechanical disorders, and comorb…
Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the stimulating effect on the organs of genitourinary system. Purpose of study. Study of stimulating effect on cellular proliferation of…
Introduction. Chronic non-communicable diseases (NCDs) account for 75% of global mortality, while traditional treatment paradigm demonstrates inability to contain epidemiological burden. Artificial intelligence (AI) technologies combined with telemedicine enab…
Introduction. Adenomas are the most common disease affecting the pituitary gland. Most of these tumors can be successfully treated. The main method is transsphenoidal resection. The exception is prolactinomas, which are treated with dopamine agonists. Objectiv…
Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the proliferotropic effect on the internal organs of organism. Purpose of study. Study of proliferotropic effect of short peptides and p…
Atherosclerosis and the installation of stents can be considered as a model of premature aging of the body. These processes are associated with chronic inflammation, oxidative stress, loss of cellular function, and impaired regeneration, which makes them a con…
Introduction: Studying the relationship between functional dyspepsia and gut microbiota will provide insight into the role of individual microorganisms and their metabolic products in the development of this pathology. The aim of the study was to analyze the m…
Introduction. It is assumed that in degenerative diseases of the retina, photostimulation with fractal dynamics signals activates neuroplasticity, increasing the effectiveness of visual rehabilitation. Previously, we demonstrated the positive effect of fractal…
Relevance. Iron deficiency anemia is a disease present all over the world and maintaining a high incidence rate of both general and primary morbidity despite various options for correction and prevention of this pathology. Molecular genotyping opens up new pos…
Introduction. Due to the rapidly growing incidence of tumor pathology of the thyroid gland, the range of molecular genetic research methods used to study the targets of targeted drugs, prognosis and surgical tactics is growing. Aim. To study the frequency of m…
Introduction. Up to 20% of tuberculosis patients suffer from malignant neoplasms. In this case, the combination of both diseases in the lung is a particular problem. More than 60% of patients cannot complete combination therapy due to drug-resistant MBT. The a…
Introduction. In clinical experiments with various pathologies leading to the activation of POL, it was found that one of the most important areas of correction of oxidative stress is the use of drugs with the properties of antioxidants and antihypoxants [6, 7…
Introduction. One of the actual task of modern biology and medicine. Is the creation of bioregulator preparation, which can stimulate the neuroendocrine system of organism. Purpose of study. Study of effect of polypeptide complex from brain cortex (PPCbc) and …
Introduction. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that is highly expressed in healthy lungs and performs homeostatic function there. However, the exact mechanisms of development of these diseases remain unk…
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation balanced status in the organism tissues is one of the actual task of modern biology and medicine. Purpose of study. Effect of encoded amino acids combination…