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PROTEASOME FUNCTIONING IN PRETUMORAL AND NEOPLASTIC HUMAN EPITHELIUM

Sidenko E.A., Kakurina G.V., Cheremisina O.V., Shashova E.E., Kolegova E.S., Kondakova I.V.

The review describes the characteristics of the ubiquitin-proteasome system involved in proteins degradation and its role in the transition of pretumor changes of the epithelium to cancer. According to modern concepts, the ubiquitin-proteasome system is active…