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Molecular Medicine
Found: 6
Introduction. Neurotoxicity is a common complication of chemotherapy that negatively affects the quality of life of cancer patients. Damage to the nervous system affects both the peripheral nerves (peripheral neuropathy) and the central nervous system (chemo b…
The review describes the characteristics of the ubiquitin-proteasome system involved in proteins degradation and its role in the transition of pretumor changes of the epithelium to cancer. According to modern concepts, the ubiquitin-proteasome system is active…
Introduction. Aproblem of finding of new markers of the development and progression of gastric cancer is actual. In this context, investigations on the role of proteolytic system sin this pathologyare gaining in importance. The aim of the study. The study of t…
Introduction. The search for criteria for the prediction of the efficacy of targeted therapies will allow not only to optimize the readings, but also to improve the results of treatment of patients with metastatic kidney cancer. The aim of the study is the inv…
Introduction. The features of pathogenesis of main tumors of the female reproductive system are determined by the impact of estrogen on target tissues. In this connection there appears the need to study the regulation of estrogen and progesterone receptors in …
In present study, we investigated the proteasome and calpain activities in patients with endometrial hyperplasia (EH) and endometrial cancer (EC), as well as proteasome subunit composition in EC tissue. EC development was shown to be associated with increased …