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Rationale for the use of N-acetylcysteine as a radioprotector during liver irradiation

Demyashkin G.A., Vadyukhin M.A., Shchekin V.I., Belokopytov D.V.

Introduction. Radiotherapy carries a risk of liver damage: radiation-induced liver disease develops in 5 – 10% of cases after gamma-irradiation at 30 Gy, driven by oxidative stress and depletion of endogenous antioxidant defense. Existing radioprotectors, such…