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Molecular Medicine Peer-reviewed scientific journal

Found: 4

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2021

PHASE I CLINICAL STUDY OF A NEW RADIOPHARMACEUTICAL BASED ON RECOMBINANT TARGET MOLECULES DARPIN9_29 LABELED WITH 99mTECHNETIUM FOR RADIONUCLIDE DIAGNOSIS OF THE Her2/neu-POSITIVE BREAST CANCER

Introduction. The main attention of researchers is paid to the study of one of the members of the EGF family – the receptor of epidermal growth factor 2 (Her2/neu), the overexpression of which is detected in 15–20% of cases of invasive breast cancer and had an…

10.29296/24999490-2021-02-06Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2021

SINGLE-PHOTON EMISSION COMPUTERIZED TOMOGRAPHY WITH 99mTc-DARPin9_29 IN DIAGNOSTICS OF BREAST CANCER WITH Her2/neu OVEREXPRESSION: FIRST CLINICAL EXPЕRIENCE

Introduction. In recent years, alternative framework proteins are used for the targeted radionuclide imaging. Molecules of DARPin (Design Ankyrin Repeat Protein) are one of the representatives of scaffolds. Despite the continued increase in the number of molec…

10.29296/24999490-2021-01-06Details ↗
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2018

INVESTIGATIONS OF THE 125I-LABELLED TARGET MOLECULES DARPIN9_29 FOR RADIONUCLIDE DIAGNOSTICS OF MALIGNANT TUMORS WITH HER2/NEU OVEREXPRESSION

Introduction. Her2/neu is one of the most studied molecular target the overexpression of which is associated with poor prognosis and aggressive course of the disease. The use of modern non-invasive radionuclide techniques with the application of highly affinit…

10.29296/24999490-2018-06-07Details ↗
ОБЗОР2018

PROSTATE-SPECIFIC MEMBRANE ANTIGEN: MODERN POSSIBILITIES IN THE DIAGNOSIS OF PROSTATE CANCER

Diagnosis and determination of tumor process in patients with prostate cancer are the most urgent problems of modern оncology. Prostate-specific membrane antigen (PSMA) is one of the most promising molecular targets for the diagnosis of prostate cancer. The le…

10.29296/24999490-2018-04-01Details ↗

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