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Molecular Medicine
Found: 65
Relevance. PARP inhibitors (PARPi), have emerged as a significant development in the treatment of high-grade serous ovarian cancer that is associated with mutations in BRCA1/2 and genes of other homologous recombination proteins. These drugs exploit synthetic …
Introduction. Cancer drug resistance is driven among others, by non-genetic mechanisms. These processes may involve transcription factors dysregulation, modifications in gene expression, as well as epigenetic mechanisms such as DNA methylation, histone modific…
Introduction. Obesity can no longer be adequately described by body mass index alone. Similar BMI values may coexist with different fat distribution, inflammatory burden, neuroendocrine dysregulation, psychobehavioral traits, and risks of organ dysfunction. Ob…
This review systematizes current data on branched-chain aminotransferases (BCATs). Their molecular structure, classification as fold type IV pyridoxal phosphate (PLP)-dependent enzymes, and catalytic features are discussed in detail. The differences between th…
Metabolic syndrome (MS) is a cluster of conditions including abdominal obesity, hypertension, dyslipidemia, and hyperglycemia that are very common in developed countries. The prevalence of MS increases annually. In recent years, a significant increase in the p…
Currently, there is no existing data on the role of asprosin and meteorin-like protein (Metrnl) in the pathogenesis of obesity in children. Purpose of the study. To assess the relationship between the levels of adipomio-cins asprosin and Metrnl with body compo…
Relevance. Primary malignant neoplasms of bones and articular cartilage account for about 0.2% of all cancer cases and are characterized by an aggressive course, high tendency to metastasize, and resistance to therapy, which leads to unsatisfactory survival ra…
Purpose of the review. The purpose of this review was to summarize the available relevant data on pathogenetic mechanisms in the formation of steroid resistance in severe bronchial asthma. Material and methods. The analysis of domestic sources on the CyberLeni…
Introduction. In general, the physiological response of tissues to external stresses is not linear in accordance with Hooke's law. Biological tissues are known to exhibit a nonlinear relationship between stress and strain, although the origins of this nonlinea…
Introduction. Cancer cell drug resistance in melanoma is associated with evasion of apoptosis-induced stimuli. Assessing the level of expression of the BCL2 and SIRT1 genes in distant organs and the tumor node makes it possible to assess the resistance of mela…
Aim of the study was to establish the significance of TR-receptor, P2X1-receptor and P2Y-receptor synergism for the efficiency of TC aggregation in patients with different sensitivity to non-selective NSAIDs, which will allow us to approach an understanding th…
Introduction. An increasing number of reports of long-term negative consequences of COVID-19, characterized by chronic inflammation, tissue hypoxia, oxidative stress, metabolic changes at the level of all body systems, determines the search for criteria for as…
Introduction. It is known that in the pathogenesis of caries and non-carious lesions of teeth, an important role is played by enamel resistance, which is determined by numerous factors, among which the structure and physical and mechanical properties of tooth …
Introduction. The use of mesenchymal stem cells (MSCs) is recognized as a promising direction for the treatment of diseases with a predominance of inflammation and sclerosis in the pathogenesis, which includes nephrotuberculosis (NT). Target. Studying the effe…
Despite significant advance in clear cell renal cell carcinoma treatment, immune checkpoint inhibitors (ICIs) still have limited therapeutic efficacy. Taking into account the resistance to immunotherapy, observed in malignant neoplasms, the search for predicti…
This review is devoted to summarizing the available data on the expression of long non-coding RNAs (lncRNAs) in lung cancer cells and tissues, their role in tumorigenesis, association with clinical and morphological characteristics and disease prognosis. The p…
Introduction. The search for molecular markers of adverse treatment outcomes in individuals with pulmonary tuberculosis (PT) is relevant due to the worldwide increase in drug resistance of Mycobacterium tuberculosis (MBT) strains to anti-tuberculosis drugs (PT…
Introduction. Entry of inorganic and organic nanomaterials through respiratory tract, skin and digestive system increases the risks of immunological disorders, hereditary and oncological diseases. Localization and stability of nanoparticles are determined by t…
Introduction. There is take place increasing in the incidence of obesity among children and adolescents in the world. However, until now there are not exist clear views about mechanisms of that phenomenon. The aim of study. The purpose of that work is comparat…
Introduction. Overcoming resistance to anticancer drugs in the treatment of malignant neoplasms is an urgent problem of recent decades. Unfortunately, there is no single mechanism for the development of resistance. Alterations that occur in a normal cell durin…