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CYTOTOXIC ACTIVITY OF THE IONOPHORE ANTIBIOTIC SALINOMYCINAND ITS COMBINATION WITH ANTICANCER PREPARATIONS AGAINST HUMAN MELANOMA CELLS

Moskaleva E.Yu., Kondrasheva I.G., Popova O.N., Semochkina Yu.P., Shmargun A.M., Severin S.E.

Salinomycin is referred to the group of the polyether antibiotics with ionophore activity. Currently salinomycin is considered as a potential anticancer drug. The aim of this work was to investigate the cytotoxic activity of salinomycin against MDR1+ (Mel-8) a…